A theoretical study of the thermodynamic driving
forces and kinetics of focal adhesion dynamics

Krishna Garikipati
Mechanical Engineering and
Michigan Center for Theoretical Physics
University of Michigan

Abstract

Focal adhesions constitute a type of structure by which cells attach to substrates. They mediate cell traction and migration, and form central components of the pathway by which cells mechanically sense their environment. It is now increasingly believed that at least some of a cell's biochemical response is regulated by mechanical signaling, and even much of the biochemical life of a cell has an eventual mechanical purpose. Focal adhesions orchestrate much of this action, so an understanding of their response has become an important quest to cell biologists and biophysicists. In this talk I will focus on the dynamics that is displayed by focal adhesions under mechanical and chemical influences. Consider this: A piece of tape adhering to a surface can be peeled off by a force. Focal adhesions, the "bits of tape" by which cells adhere to substrates, also appear to peel under the application of force. However, in certain force regimes they also grow, and in others, slide along the force. I will draw upon what has been learnt, from other branches of Physics, about thermodynamic driving forces and kinetics in an attempt to identify the physical mechanisms that control focal adhesion dynamics.

Thursday, January 31st
337 Towne Bldg.
2:00 – 3:00 p.m.