Micro and Nano Fluidics Areas of Research:
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Micro and Nano Fluidics:
A System for Pathogen Detection in Oral Fluids
In collaboration with colleagues at the UPenn School of Dental Medicine, Leiden University, and a company (OraSure Technologies), we are developing an integrated system for the detection of pathogens in oral fluids at the point of sample collection. The system consists of a disposable sample collector, a disposable cassette, and an analyzer. The system facilitates multiple analysis paths for the processing and identification of antibodies, antigens, DNA, and RNA. The pneumatically driven cassette contains flow conduits and reaction chambers for cell lysis, DNA isolation, PCR, and detection. The detection is facilitated through the use of membranes modified with appropriate surface chemistries and Up-converting phosphors that absorb infrared energy and subsequently emit it as visible light.
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Our corporate partner:
Penn School of Dental Medicine
Professor
Dan Malamud
Biochemistry Department
School of Dental Medicine
